MR of brain radiation injury: experimental studies in cats.

نویسندگان

  • C Hecht-Leavitt
  • R I Grossman
  • W J Curran
  • J T McGrath
  • D N Biery
  • P M Joseph
  • D F Nelson
چکیده

Two of six cats receiving small-field, single-dose, brain irradiation of 35 Gy with 6 MeV photons developed brain abnormalities in the irradiated area on MR images at 6 and 8 months, respectively, after treatment. The lesions were of high intensity on T2-weighted images and did not enhance after IV administration of gadolinium-DTPA. An additional lesion in one of these cats displayed high signal on T2-weighted images and enhanced on T1-weighted images after IV gadolinium-DTPA. Pathologic correlation revealed that the nonenhancing T2-weighted lesions consisted of edema or demyelinated regions without inflammation while the gadolinium-enhanced lesion demonstrated necrosis with inflammatory infiltrate. Focal brain irradiation may produce noninflammatory demyelination and necrosis. These histologic entities may be potentially distinguished on MR with IV gadolinium-DTPA.

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عنوان ژورنال:
  • AJNR. American journal of neuroradiology

دوره 8 3  شماره 

صفحات  -

تاریخ انتشار 1987